Giant/Giantess
Acromegaly is a disease affecting the pituatary gland that causes the person to grow abnormally large. The giant Robert Wadlow, who worked with Ringling Brothers Circus, asked to be buried in a concrete coffin to avoid ending up in some "freak" museum after his death!
Giants populate the Bible and Greek literature; Gulliver's Travels explores the experiences of both gigantism and dwarfism; and many twentieth-century writers, including Vladimir Nabokov and John Barth, have used freaks as fictional characters or inspired from their real lives.
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